M. Zinovieva, N. Kurdil, P. Zhminko, M. Prodanchuk, O. Kravchuk, M. Velychko

LI Medved’s Research Centre of Preventive Toxicology, Food and Chemical Safety, Ministry of Health, Ukraine (State Enterprise), Kyiv, Ukraine

ABSTRACT. The current standards of treatment the acute OPC poisoning with anticholinesterase action remain insufficient, despite the significant number of researches in this area conducted in the world. One of the ways to solve this problem is to use a wider range of pathogenetically determined pharmacologic agents.

The Aim of the Research. To observe and summarize the published results of investigation the pharmacological therapeutic appliance for acute OPC poisoning at the stages of preclinical and early clinical evaluation.

Methods. System content analysis of literature data using the PubMed and Google Scholar databases.

Results and Conclusions. The investigation of pharmacological therapeutic appliance effectiveness for acute anticholinesterase OPC poisoning remains relevant when taking into account the complexity of the intoxication pathogenesis. The main lines of pharmacological agents’ research for the acute anticholinesterase OPC poisoning include the study of n-cholinoreceptor antagonists, benzodiazepine receptor agonists, NMDA-receptor antagonists, H1-histamine receptor antagonists, alpha-adrenergic receptor agonists, enzymatic antidote, antioxidants, agonists of beta-adrenergic blockers, and also magnesium sulfate, sodium bicarbonate, lipid emulsions. The investigations of clinically available therapeutic appliance continue both in animal experiments and at the clinical application stage. Such investigations are also important given the need for poisoning emergency care under conditions when specific therapies are missing or limited.

Keywords: organophosphorus compounds, acute poisoning, therapeutic appliance.

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Стаття надійшла до редакції 09.12.2022

The article was received by the editors on December, 12th, 2022