LI Medved’s Research Centre of Preventive Toxicology, Food and Chemical Safety, Ministry of Health, Ukraine (State Enterprise), Kyiv, Ukraine
ABSTRACT. Objective. To analyze and generalize the data of modern literature on the use of rabbits for laboratory experimental studies and substantiate the prospects for their further use.
Materials and Methods. Analytical methods were used in the work: collection of scientific information on the problem, analysis of published data from PubMed libraries and scientific generalization of the results.
Results and Conclusions. Principles have been substantiated regarding the prospects for the further use of rabbits for laboratory experimental studies. Science has advanced long ago, and ethical alternative scientific testing methods have now been developed and implemented to provide more reliable results. But if in some areas of scientific research, rabbits have ceased to be used altogether, then in other areas, on the contrary, the use of rabbits is rapidly increasing every year. Currently, there is no alternative to using rabbits for the production of antibodies, recombinant proteins. Testing in laboratory animals is the best method for detecting consequences such as cancer and birth defects. Genetically modified rabbits - new perspectives opening up in scientific research. With the development of new technologies for genome editing, especially CRISPR/Cas9 and its modifications, it has become possible to obtain with high efficiency an increasing number of transgenic animals with precisely specified genetic modifications for solving a wide variety of problems. The use of animals in experiments is critical for some areas of scientific research, since this complexity of the structure of the organism cannot be duplicated in cell culture or using computer models.
Key Words: rabbits, maintenance, testing on animals, human health.
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Надійшла до редакції 17/03/2021